There's a long history of drugs that work really well but have bad side-effects that are even worse than the ailment they cure.

Many of the side effects (unlike the positive effects) take years to play out. There's a lag between the good stuff and the bad stuff.

That's actually a descriptor of hundreds of drugs and treatments that have never made it past a phase trial. Efficacy is apparently relatively easy to achieve - though there's some discrepancies when efficacy studies are performed by people incentivized to benefit vs. by people who have no incentive.

There is already a long list of weight loss drugs that we've "discovered" have bad side effects. They all work really, really well. They were all "miracle" drugs at one point.

In medical intervention (as in other human endeavors) there are really very few perfect solutions that have no drawbacks. Everything has a trade-off. Even healthy diet and exercise have trade-offs. If you can't think of any, you're not trying hard enough.

I will be quite surprised if we find out that ozempic is found to have little or no trade-offs.

I'm hopeful, of course, but the history of weight-loss drugs is already littered with the side-effects and in many cases corpses resulting from previous miracle drugs.